Linux distro vs. language package management

In the "normal" Linux distributions I've used, there's always this thing of, e.g.: "oh, no, that's the system Python*. Don't use that; it's only for other distro-managed software. You want a venv where you use pip (or whatever) to get the right dependencies."

I get why. But I'm curious: in distros like Nix or Guix, can you (easily) have the language-specific package manager handle the system-wide install of that language?

* not just Python, of course

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