Hackers' Pub

Syntax	Description	Examples
`"` keyword `"`	Finds the string within quotes, including spaces. Case-insensitive. (Escape quotes inside with `\"`)	`"Hackers' Pub"`
`from:` handle	Finds content written by the specified user.	`from:hongminhee` `from:hongminhee@hollo.social`
`lang:` ISO 639-1	Finds content written in the specified language.	`lang:en`
`#` tag	Finds content with the specified tag. Case-insensitive.	`#HackersPub`
condition condition	Finds content that satisfies both conditions on either side of the space (logical AND).	`"Hackers' Pub" lang:en`
condition `OR` condition	Finds content that satisfies at least one of the conditions on either side of the OR operator (logical OR).	`#HackersPub OR "Hackers' Pub" lang:en`
`(` condition `)`	Combines the operators within the parentheses first.	`(#HackersPub OR "Hackers' Pub" OR "Hackers Pub") lang:en`

Glyph @glyph@mastodon.social

4/1/2025, 12:54:00 AM

Public

New blog; alternate title: "in which the author attempts to both empathize with and critique the data-packrat impulse that seems to be driving a lot of toxic behavior in the software industry right now"

https://blog.glyph.im/2025/03/a-bigger-database.html

A Bigger Database

We do what we can, because we must.

blog.glyph.im

Link author: Glyph@glyph@mastodon.social

nick @nickzoic@aus.social

4/1/2025, 1:12:34 AM

Public

@glyph good article, and you're right about biomedical research. There *are* machine learning advances in biomedicine: things like protein variant effect prediction[*], but these aren't just "pour all of biorxiv into an LLM and shake well"
they're specific investigations which use the data gathered in biological models and clinical records to build and validate a predictive model. So, you know, actual science.

[*] eg: https://www.nature.com/articles/s41588-023-01465-0

Genome-wide prediction of disease variant effects with a deep protein language model - Nature Genetics

A modified framework leveraging a protein language model (ESM1b) is used to predict all possible 450 million missense variant effects in the human genome and shows potential for generalizing to more complex genetic variations such as indels and stop-gains.

www.nature.com · Nature

If you have a fediverse account, you can quote this note from your own instance. Search https://aus.social/users/nickzoic/statuses/114260046909471236 on your instance and quote it. (Note that quoting is not supported in Mastodon.)